洛桑聯(lián)邦理工學(xué)院教授Francesco Stellacci講述超分子廣譜抗病毒藥物

直播時(shí)間：2023年7月14日（周五）20:00-21:30 直播平臺(tái)： 科學(xué)網(wǎng)APP https://weibo.com/l/wblive/p/show/1022:2321324923397153882372（科學(xué)網(wǎng)微博直播間鏈接） 科學(xué)網(wǎng)微博 科學(xué)網(wǎng)視頻號(hào) 北京時(shí)間2023年7月14日晚八點(diǎn)，iCANX Talks 第152期邀請(qǐng)到洛桑聯(lián)邦理工學(xué)院 Francesco Stellacci 教授分享開發(fā)廣譜抗病毒藥物方面長達(dá)十余年的努力！更多精彩，敬請(qǐng)期待！ 【嘉賓介紹】 Francesco Stellacci Ecole Polytechnique Fédérale de LausanneSymmetry Supramolecular Broad-Spectrum Antivirals 【Abstract】 Viral infections are a great threat for modern society, there are thousands of people that die every year because of them (mostly in under-developed countries) and many more have a lower quality of life because of them. Furthermore, it is become apparent that pandemic infection can have enormous consequences on global health as well as on the economy of the entire world. 病毒感染對(duì)于現(xiàn)代社會(huì)是巨大的威脅，每一年有數(shù)以千計(jì)的人因此致死（大多數(shù)發(fā)生在欠發(fā)達(dá)國家），更多的人由于病毒感染生活質(zhì)量降低。此外，瘟疫感染對(duì)于整個(gè)世界的衛(wèi)生以及經(jīng)濟(jì)可以造成極為嚴(yán)重的后果。 In this talk I will summarize a decade-long effort in my laboratory to develop broad-spectrum antivirals. The approach that will be presented is different from most biological approach as it is focused on an extracellular mechanism that affect the structural integrity of the virus rendering them non infective irreversibly. I will discuss the development of the compounds that we are investigating and their putative mechanism. In vitro, ex vivo, and in vivo example of the efficacy of such compounds will be discussed. 在本次講座中我會(huì)總結(jié)我們實(shí)驗(yàn)室在開發(fā)廣譜抗病毒藥物方面長達(dá)十余年的努力。我將要介紹的方法與大多數(shù)生物方法不同，因?yàn)樗鼘Ｗ⒂谟绊懖《窘Y(jié)構(gòu)完整性的細(xì)胞外機(jī)制，使它們不可逆地不具有感染性。我將討論我們正在研究的化合物的開發(fā)及其假定的機(jī)制和這些化合物在體外、體內(nèi)和離體的療效實(shí)例。 【BIOGRAPHY】 Prof. Francesco Stellacci got his degree in Materials Engineering at the Politecnico di Milano in 1998 with Prof. Zerbi. He then moved as a post-doc with Prof. J.W. Perry in the Department of Chemistry at the University of Arizona. In 2002 he became as assistant professor in the Department of Materials Science and Engineering at MIT (Cambridge, USA). There he became associate professor with tenure in 2009. In 2010, he moved as a full professor to EPFL where he holds the Constellium chair. Stellacci has published more than 130 papers and has more than 15 patent applications. He has won numerous awards, among the the Technology Review TR35 ’top innovator under 35’, the Popular Science Magazine ’Brilliant 10’, and the EMRS EU40. He is a Fellow of the Royal Society of Chemistry, of the Global Young Academy, and of the European Academy of Sciences. Francesco Stellacci教授于1998年在米蘭理工大學(xué)獲得材料工程學(xué)位，師從Zerbi教授。他隨后在亞利桑那大學(xué)化學(xué)系J. W. Perry教授課題組進(jìn)行博士后研究。在2002年他成為麻省理工學(xué)院材料科學(xué)與工程系助理教授（位于美國劍橋）。此后他于2009年成為副教授并獲得終身教職。在2010年，他成為EPFL全職教授，并擔(dān)任Constellium。Stellacci已經(jīng)發(fā)表了130多篇論文，并有超過15項(xiàng)專利申請(qǐng)。他贏得了許多獎(jiǎng)項(xiàng)，其中包括《技術(shù)評(píng)論》TR35"35歲以下的頂級(jí)創(chuàng)新者"，《大眾科學(xué)》雜志 "輝煌10人"，以及EMRS EU40。他是皇家化學(xué)學(xué)會(huì)、全球青年學(xué)院和歐洲的。 特別聲明：本文轉(zhuǎn)載僅僅是出于傳播信息的需要，并不意味著代表本網(wǎng)站觀點(diǎn)或證實(shí)其內(nèi)容的真實(shí)性；如其他媒體、網(wǎng)站或個(gè)人從本網(wǎng)站轉(zhuǎn)載使用，須保留本網(wǎng)站注明的“來源”，并自負(fù)版權(quán)等法律責(zé)任；作者如果不希望被轉(zhuǎn)載或者聯(lián)系轉(zhuǎn)載稿費(fèi)等事宜，請(qǐng)與我們接洽。